My research addresses the lived experiences and voices of the people imprisoned by the Inquisition in the Americas in the early seventeenth Century through prisons in Cartagena de Indias, Lima, and Mexico City. With an eye on gender and religious practice, particularly for Africans and Portuguese. I discuss embodied and gendered experiences with incarceration and the many forms of violence and resistance within early modern prisons. The arrests I study came as part of two religious conspiracies pursed by a family of Inquisitors, and follows the career of one influential Inquisitor, showing how religion was used to craft conspiracies allowing for the imprisoning of political rivals. I consider the ways in which the incarcerated expressed their wants and needs, their lives, who they were, and the physical and emotional sensations they experienced that shaped major historical events. By focusing on the voices of the incarceration, I unsettle hierarchies of power to show that gender and sex played a role in imprisonment and resistance. With these experiences and interconnected events across the Iberian Atlantic, I argue that these three prisons set a model for mass incarceration that allowed Spain a far-reaching control over its colonial citizens.